Title : Dexamethasone attenuates methacholine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-κB activation.

Pub. Date : 2018 Jan

PMID : 29083535






3 Functional Relationships(s)
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1 Dexamethasone attenuates methacholine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-kappaB activation. Methacholine Chloride nuclear factor kappa B subunit 1 Homo sapiens
2 Western blotting revealed that, after incubation with 10-4 mol/L methacholine, NF-kappaB increased significantly, by 186.67%, compared with the untreated control group. Methacholine Chloride nuclear factor kappa B subunit 1 Homo sapiens
3 CONCLUSION: NF-kappaB activation is important for inhibition of p-CREB/AQP5 expression after methacholine intervention, and dexamethasone adjusts it to the opposite side. Methacholine Chloride nuclear factor kappa B subunit 1 Homo sapiens