Title : The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.

Pub. Date : 2018 May

PMID : 29080374






1 Functional Relationships(s)
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1 The expression of TNF-alpha and IL-6 was significantly reduced by treatment with a selective PERK inhibitor, GSK2606414, and by gene silencing against PERK and activating transcription factor 4 (ATF4) transcripts. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine interleukin 6 Homo sapiens