Pub. Date : 2017 Nov
PMID : 29068287
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to activate p14 expression via promoter hypermethylation to induce p53-dependent apoptosis in human hepatocytes. | Tretinoin | tumor protein p53 | Homo sapiens |
2 | All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to activate p14 expression via promoter hypermethylation to induce p53-dependent apoptosis in human hepatocytes. | Tretinoin | tumor protein p53 | Homo sapiens |
3 | In this study, we found that the oncogenic hepatitis B virus (HBV) X protein (HBx) of HBV, derived from both overexpression and 1.2-mer replicon systems, suppresses ATRA-induced apoptosis in p53-positive human hepatocytes. | Tretinoin | tumor protein p53 | Homo sapiens |
4 | As a result, HBx was able to impair the potential of ATRA to activate apoptosis-related molecules, including Bax, p53-upregulated modulator of apoptosis, caspase-9, caspase-3 and poly (ADP-ribose) polymerase. | Tretinoin | tumor protein p53 | Homo sapiens |
5 | In conclusion, the present study provides a new oncogenic action mechanism of HBx, namely by suppressing the anticancer potential of ATRA to induce p53-dependent apoptosis in HBV-infected hepatocytes. | Tretinoin | tumor protein p53 | Homo sapiens |