PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29068287-1	2017	All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to activate p14 expression via promoter hypermethylation to induce p53-dependent apoptosis in human hepatocytes.	Tretinoin	0-23	tumor protein p53	Homo sapiens	162-165	
29068287-1	2017	All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to activate p14 expression via promoter hypermethylation to induce p53-dependent apoptosis in human hepatocytes.	Tretinoin	25-29	tumor protein p53	Homo sapiens	162-165	
29068287-2	2017	In this study, we found that the oncogenic hepatitis B virus (HBV) X protein (HBx) of HBV, derived from both overexpression and 1.2-mer replicon systems, suppresses ATRA-induced apoptosis in p53-positive human hepatocytes.	Tretinoin	165-169	tumor protein p53	Homo sapiens	191-194	
29068287-4	2017	As a result, HBx was able to impair the potential of ATRA to activate apoptosis-related molecules, including Bax, p53-upregulated modulator of apoptosis, caspase-9, caspase-3 and poly (ADP-ribose) polymerase.	Tretinoin	53-57	tumor protein p53	Homo sapiens	114-117	
29068287-5	2017	In conclusion, the present study provides a new oncogenic action mechanism of HBx, namely by suppressing the anticancer potential of ATRA to induce p53-dependent apoptosis in HBV-infected hepatocytes.	Tretinoin	133-137	tumor protein p53	Homo sapiens	148-151