Title : Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality.

Pub. Date : 2018 Feb

PMID : 29067790






1 Functional Relationships(s)
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1 Candidate screening revealed that acetylation state of lysine 243 on BubR1 (BubR1-K243, an integral part of the spindle assembly checkpoint complex) functions during oocyte meiosis, and acetylation-mimetic mutant BubR1-K243Q results in the very similar phenotypes as Sirt2-knockdown oocytes. Lysine sirtuin 2 Mus musculus