Pub. Date : 2018 Sep
PMID : 29066411
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | We herein investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response in the protection of GA against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in L02 cells. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | We herein investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response in the protection of GA against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in L02 cells. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Additionally, GA induced phosphorylated activation of extracellular regulated kinase (ERK), and ERK inhibitor PD98059 partially decreased GA-induced hepatoprotection, and downregulated the increased protein expressions of Nrf2, GCLC and HO-1 induced by GA. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Furthermore, molecular docking indicated that GA possibly competed with Nrf2 for binding to Keap1. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | Collectively, GA effectively protects against t-BHP-induced hepatotoxicity via inducing ERK/Nrf2-mediated antioxidative signaling pathway. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 7 | Meanwhile, GA disturbs protein-protein interaction between Keap1 and Nrf2 which might also contribute to nuclear translocation of Nrf2. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 8 | Meanwhile, GA disturbs protein-protein interaction between Keap1 and Nrf2 which might also contribute to nuclear translocation of Nrf2. | Gallic Acid | NFE2 like bZIP transcription factor 2 | Homo sapiens |