Title : (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways.

Pub. Date : 2017 Nov

PMID : 29061787






3 Functional Relationships(s)
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1 (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens
2 DOX induced the overexpression of MDR1 mRNA and increased the phosphorylation of Akt, ERK1/2, p38 MAPK and JNK. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens
3 CONCLUSION: EGCG inhibited DOX-induced overexpression of P-gp through the coordinate inhibitory action on MEK/ERK and PI3K/Akt signaling pathways. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens