Title : From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome.

Pub. Date : 2017 Oct 12

PMID : 29057057






1 Functional Relationships(s)
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1 Initial optimization of a 3-substituted indazole hit compound targeting the kinase PIM1 focused on improving selectivity over GSK3beta through consideration of differences in the ATP binding pockets. Adenosine Triphosphate Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens