Title : Novel p-carborane-containing multitarget anticancer agents inspired by the metabolism of 17β-estradiol.

Pub. Date : 2017 Dec 15

PMID : 29054710






1 Functional Relationships(s)
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1 The female hormone 17 beta-estradiol (E2) is synthesized from estrone by steroid sulfatase (STS), and metabolized into 2-methoxyestradiol (2-ME), whereby the biological activity of the latter is substantially different from that of E2. Estradiol steroid sulfatase Homo sapiens