Protein Name steroid sulfatase
Organism Homo sapiens
Gene ID 412
Gene Symbol


UniProt P08842 (STS_HUMAN), A0A590UJL0 (A0A590UJL0_HUMAN), A6PYA4 (A6PYA4_HUMAN), Q0W975 (Q0W975_HUMAN)
Relationships Total Number of functionally related compound(s) : 311
Total Number of Articles : 305

steroid sulfatase

Gene Summary

This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

  • steryl-sulfatase
  • arylsulfatase C
  • estrone sulfatase
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