Title : Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM.

Pub. Date : 2018 Jan 1

PMID : 29051323






1 Functional Relationships(s)
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1 Derepression of BIM expression by depletion of ZEB1 or treatment with the BH3 mimetic ABT-263 to enhance "free" cellular BIM levels both led to resensitization of mesenchymal EGFR-mutant cancers to EGFRi. bim epidermal growth factor receptor Homo sapiens