Title : Changes in platelet Bax levels contribute to impaired platelet response to thrombin after cardiopulmonary bypass: prospective observational clinical and laboratory investigations.

Pub. Date : 2017 Dec 1

PMID : 29040496






2 Functional Relationships(s)
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1 Results: Thrombin-induced platelet calcium mobilisation and platelet-surface glycoprotein Ib (GPIb) expression were lowest at weaning from CPB and did not recover on postoperative day one. Calcium coagulation factor II, thrombin Homo sapiens
2 Conclusions: CPB increases platelet Bax expression, which contributes to reduced platelet-surface GPIb expression and thrombin-induced platelet calcium changes. Calcium coagulation factor II, thrombin Homo sapiens