Title : Dramatic clinical and radiographic response to BRAF inhibition in a patient with progressive disseminated optic pathway glioma refractory to MEK inhibition.

Pub. Date : 2017 May

PMID : 29040023






1 Functional Relationships(s)
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1 We report a patient with disseminated LGG with the BRAFV600E mutation, which was refractory to selumetinib, a MEK inhibitor, but subsequently showed immediate clinical and radiographic response to dabrafenib, a BRAF inhibitor, with sustained effect for 9 months prior to clinical progression. AZD 6244 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens