Pub. Date : 2017 Nov 16
PMID : 29036434
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Following GTP hydrolysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B. | Guanosine Diphosphate | eukaryotic translation initiation factor 2B subunit delta | Homo sapiens |
| 2 | We present: (i) a novel mechanism for the inhibition of eIF2B activity, whereby eIF2alpha phosphorylation destabilizes an autoregulatory intramolecular interaction within eIF2alpha; and (ii) the first structural model for the complex of eIF2B with its substrate, eIF2-GDP, reaction intermediates, apo-eIF2 and eIF2-GTP, and product, TC, with direct implications for the eIF2B catalytic mechanism. | Guanosine Diphosphate | eukaryotic translation initiation factor 2B subunit delta | Homo sapiens |