Pub. Date : 2017 Oct 13
PMID : 29027899
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using a pure in vitro reconstitution system, we demonstrate that metformin acts through the v-ATPase-Ragulator lysosomal pathway to coordinate mTORC1 and AMPK, two hubs governing metabolic programs. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | We further show in Caenorhabditis elegans that both v-ATPase-mediated TORC1 inhibition and v-ATPase-AXIN/LKB1-mediated AMPK activation contribute to the lifespan extension effect of metformin. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |