PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29027899-3	2017	Using a pure in vitro reconstitution system, we demonstrate that metformin acts through the v-ATPase-Ragulator lysosomal pathway to coordinate mTORC1 and AMPK, two hubs governing metabolic programs.	Metformin	65-74	CREB regulated transcription coactivator 1	Mus musculus	143-149	
29027899-4	2017	We further show in Caenorhabditis elegans that both v-ATPase-mediated TORC1 inhibition and v-ATPase-AXIN/LKB1-mediated AMPK activation contribute to the lifespan extension effect of metformin.	Metformin	182-191	CREB regulated transcription coactivator 1	Mus musculus	70-75