Title : Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold.

Pub. Date : 1988 Aug

PMID : 2902535






2 Functional Relationships(s)
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1 Significantly increased levels of somatostatin (by 60%), neuropeptide Y (135%) and increased activity of glutamate decarboxylase (22%) were found in the frontal cortex of rats previously treated with kainic acid. Kainic Acid glutamate-ammonia ligase Rattus norvegicus
2 Michaelis-Menten kinetics of glutamate decarboxylase revealed an increased maximal velocity (Vmax) in the frontal cortex of kainic acid-treated rats, but no change in the Km value was found. Kainic Acid glutamate-ammonia ligase Rattus norvegicus