Title : Akt Signal Transduction Pathways and Nuclear Factor-kappa B (NF-κB) Transcription as a Molecular Target of Oral Tongue Squamous Cell Carcinoma (SP-C1) Using Papua's Anthill Plant ( Myrmecodia pendans ).

Pub. Date : 2016

PMID : 29023018






5 Functional Relationships(s)
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1 On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway. ethyl acetate nuclear factor kappa B subunit 1 Homo sapiens
2 On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway. ethyl acetate nuclear factor kappa B subunit 1 Homo sapiens
3 On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway. ethyl acetate nuclear factor kappa B subunit 1 Homo sapiens
4 CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue. ethyl acetate nuclear factor kappa B subunit 1 Homo sapiens
5 CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue. ethyl acetate nuclear factor kappa B subunit 1 Homo sapiens