Pub. Date : 2018 Feb
PMID : 29022246
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In this study, we investigated the role of endogenous antioxidant alpha-lipoic acid (ALA) as ROSs scavenger in the OLGs loss and myelin degeneration during cuprizone (cup)-induced demyelination in the experimental model of MS. Our results have shown that ALA treatment significantly increased population of mature OLGs (MOG+ cells), as well as decreased oxidative stress (ROSs, COX-2 and PGE2) and apoptosis mediators (caspase-3 and Bax/Bcl2 ratio) in corpus callosum (CC). | Thioctic Acid | BCL2 associated X, apoptosis regulator | Homo sapiens |