Title : Acute nicotine disrupts consolidation of contextual fear extinction and alters long-term memory-associated hippocampal kinase activity.

Pub. Date : 2017 Nov

PMID : 29017931






2 Functional Relationships(s)
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1 Our results showed that acute nicotine administered prior to extinction sessions downregulated the phosphorylated forms of ERK1/2 in the ventral hippocampus, but not dorsal hippocampus, and JNK1 in both dorsal and ventral hippocampus on the 3rd extinction day. Nicotine mitogen-activated protein kinase 3 Homo sapiens
2 Finally, acute nicotine injections immediately after extinction sessions upregulated the phosphorylated forms of ERK1/2 in the ventral hippocampus, but did not affect JNK1. Nicotine mitogen-activated protein kinase 3 Homo sapiens