Pub. Date : 2017 Dec 1
PMID : 29016875
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |
| 2 | However, the relationship between dose and plasma concentration of duloxetine and norepinephrine transporter occupancy in the human brain has not been determined. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |
| 3 | In this study, we examined norepinephrine transporter occupancy by different doses of duloxetine. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |
| 4 | Results: Norepinephrine transporter occupancy by duloxetine was 29.7% at 20 mg, 30.5% at 40 mg, and 40.0% at 60 mg. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |
| 5 | The estimated dose of duloxetine inducing 50% norepinephrine transporter occupancy was 76.8 mg, and the estimated plasma drug concentration inducing 50% norepinephrine transporter occupancy was 58.0 ng/mL. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |
| 6 | Conclusions: Norepinephrine transporter occupancy by clinical doses of duloxetine was approximately 30% to 40% in human brain as estimated using positron emission tomography with (S,S)-[18F]FMeNER-D2. | Duloxetine Hydrochloride | solute carrier family 6 member 2 | Homo sapiens |