Pub. Date : 2017 Sep 15
PMID : 28978034
7 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation. | celastrol | NLR family pyrin domain containing 3 | Homo sapiens | ||
| 2 | Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibits subsequent caspase-1 activation and IL-1beta secretion both in vitro and in vivo. | celastrol | NLR family pyrin domain containing 3 | Homo sapiens | ||
| 3 | Notably, interruption of ASC oligomerization and autophagy activation are involved in NLRP3 inflammasome inactivation by celastrol. | celastrol | NLR family pyrin domain containing 3 | Homo sapiens | ||
| 4 | Importantly, in vivo results indicate that celastrol attenuates NLRP3 inflammasome-dependent inflammation diseases via autophagy-related pathway. | celastrol | NLR family pyrin domain containing 3 | Homo sapiens | ||
| 5 | Our results thus reveal celastrol as an inhibitor of NLRP3 inflammasome, implying the potential for clinical use of celastrol in treatment of NLRP3 inflammasome-driven inflammatory diseases. | celastrol | NLR family pyrin domain containing 3 | Homo sapiens | ||
| 6 | Our results thus reveal celastrol as an inhibitor of NLRP3 inflammasome, implying the potential for clinical use of celastrol in treatment of NLRP3 inflammasome-driven inflammatory diseases. | celastrol | NLR family pyrin domain containing 3 | Homo sapiens | ||
| 7 | Our results thus reveal celastrol as an inhibitor of NLRP3 inflammasome, implying the potential for clinical use of celastrol in treatment of NLRP3 inflammasome-driven inflammatory diseases. | celastrol | NLR family pyrin domain containing 3 | Homo sapiens | ||