Pub. Date : 2017
PMID : 28968471
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects and mechanisms of epirubicin treatment on the expressions of upstream survival signals (e.g., beta-catenin) and downstream MDR transporters (e.g., P-gp) and anti-apoptotic pathways (e.g., Bcl-2) were assessed with or without HuR knockdown (siHuR) or overexpression (overHuR; ectopic HuR or pcDNA3/HA-HuR). | Epirubicin | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Our results showed that siHuR decreased transcriptional expressions of galectin-3, beta-catenin, cyclin D1, Bcl-2, P-gp, MRP1, and MRP2 in epirubicin-treated colon cancer cells. | Epirubicin | BCL2 apoptosis regulator | Homo sapiens |
| 3 | The combined treatments of siHuR and epirubicin significantly reduced the expression of Bcl-2, but increased the expression of Bax, as well as activity and expression levels of caspase-3 and -9. | Epirubicin | BCL2 apoptosis regulator | Homo sapiens |