Title : Dexmedetomidine mitigates isoflurane-induced neurodegeneration in fetal rats during the second trimester of pregnancy.

Pub. Date : 2017 Aug

PMID : 28966649






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1 Our results demonstrate that 4 hours after inhaling isoflurane, 20 mug/kg dexmedetomidine visibly mitigated isoflurane-induced neuronal apoptosis, reversed downregulation of brain-derived neurotrophic factor expression, and lessened decreased spatial learning and memory ability in adulthood in the fetal rats. Dexmedetomidine brain-derived neurotrophic factor Rattus norvegicus