Pub. Date : 2017 Oct
PMID : 28966507
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 2 | BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 3 | BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 4 | BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 5 | TPMT genotyping is widely used for screening of AZA-related toxicity during routine clinical practice in Korea. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 6 | However, the data of TPMT genotypes and its AZA-related toxicity have not been studied in the field of dermatology. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 7 | OBJECTIVE: The aim of this study was to evaluate the genetic basis of TPMT polymorphism in Korean dermatologic patients and subsequently to investigate the relationship between mutant TPMT and adverse responses to AZA treatment. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 8 | OBJECTIVE: The aim of this study was to evaluate the genetic basis of TPMT polymorphism in Korean dermatologic patients and subsequently to investigate the relationship between mutant TPMT and adverse responses to AZA treatment. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 9 | CONCLUSION: Our results suggest that 1) TPMT polymorphisms in Korean dermatologic patients are similar to those previously reported in Asian patients with the most common mutant allele being TPMT*3C and 2) AZA can be used in the patients with these polymorphisms under a careful dosing regimen. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |