Pub. Date : 2017 Oct
PMID : 28959367
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Elacridar (GF120918), a third-generation inhibitor of ABCB1, was able to overcome resistance to docetaxel. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Additionally, knockdown of ABCB1 using small interfering RNA (si)-ABCB1 recovered sensitivity to docetaxel. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Additionally, knockdown of ABCB1 using small interfering RNA (si)-ABCB1 recovered sensitivity to docetaxel. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The results of the present study revealed that docetaxel-resistant NSCLC cells also acquired cross-resistance to EGFR-TKI therapy through mechanisms other than ABCB1, that ABCB1 serves an important role in acquired resistance to docetaxel in lung cancer, and that combination therapy with elacridar can overcome ABCB1-mediated docetaxel resistance. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The results of the present study revealed that docetaxel-resistant NSCLC cells also acquired cross-resistance to EGFR-TKI therapy through mechanisms other than ABCB1, that ABCB1 serves an important role in acquired resistance to docetaxel in lung cancer, and that combination therapy with elacridar can overcome ABCB1-mediated docetaxel resistance. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The results of the present study revealed that docetaxel-resistant NSCLC cells also acquired cross-resistance to EGFR-TKI therapy through mechanisms other than ABCB1, that ABCB1 serves an important role in acquired resistance to docetaxel in lung cancer, and that combination therapy with elacridar can overcome ABCB1-mediated docetaxel resistance. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | The results of the present study revealed that docetaxel-resistant NSCLC cells also acquired cross-resistance to EGFR-TKI therapy through mechanisms other than ABCB1, that ABCB1 serves an important role in acquired resistance to docetaxel in lung cancer, and that combination therapy with elacridar can overcome ABCB1-mediated docetaxel resistance. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | The results of the present study revealed that docetaxel-resistant NSCLC cells also acquired cross-resistance to EGFR-TKI therapy through mechanisms other than ABCB1, that ABCB1 serves an important role in acquired resistance to docetaxel in lung cancer, and that combination therapy with elacridar can overcome ABCB1-mediated docetaxel resistance. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | The results of the present study revealed that docetaxel-resistant NSCLC cells also acquired cross-resistance to EGFR-TKI therapy through mechanisms other than ABCB1, that ABCB1 serves an important role in acquired resistance to docetaxel in lung cancer, and that combination therapy with elacridar can overcome ABCB1-mediated docetaxel resistance. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |