Title : Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver.

Pub. Date : 2017

PMID : 28947922






3 Functional Relationships(s)
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Compound Name
Protein Name
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1 Lower average and promoter DNA methylation of SLC22A1, SLC22A3, and SLC47A1 was found in diabetic subjects receiving just metformin, compared to those who took insulin plus metformin or no diabetes medication. Metformin solute carrier family 22 member 1 Homo sapiens
2 Lower average and promoter DNA methylation of SLC22A1, SLC22A3, and SLC47A1 was found in diabetic subjects receiving just metformin, compared to those who took insulin plus metformin or no diabetes medication. Metformin solute carrier family 22 member 1 Homo sapiens
3 Importantly, metformin treatment did also directly decrease DNA methylation of SLC22A1 in hepatocytes cultured in vitro. Metformin solute carrier family 22 member 1 Homo sapiens