Pub. Date : 2018 Jan
PMID : 28947376
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. | Alcohols | toll-like receptor 4 | Mus musculus |
| 2 | Subsequent analysis of nucleus accumbal mRNA, revealed increased expression of TLR4-related mRNAs in mice who received alcohol during adolescence. | Alcohols | toll-like receptor 4 | Mus musculus |
| 3 | This study highlights that even a small amount of alcohol, when given during a critical neurodevelopmental period, can potentiate alcohol-related behaviours and TLR4 activation later in life. | Alcohols | toll-like receptor 4 | Mus musculus |
| 4 | Interestingly, attenuation of TLR4 before or after adolescent alcohol exposure reduced only binge alcohol intake in adulthood. | Alcohols | toll-like receptor 4 | Mus musculus |