Title : Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats.

Pub. Date : 2017 Nov 15

PMID : 28947331






3 Functional Relationships(s)
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1 Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. Ketamine brain-derived neurotrophic factor Rattus norvegicus
2 The aim of this study was to investigate whether the behavioural effects induced by the inhibition of nitric oxide (NO) synthesis by aminoguanidine or N-methyl-D-aspartate (NMDA) receptor blockade by ketamine would affect the gene expression of Bdnf and Mtor in the ventromedial prefrontal cortex in rats. Ketamine brain-derived neurotrophic factor Rattus norvegicus
3 Quantitative real-time polymerase chain reaction analyses in SD rats demonstrated that none of the treatments can change the Bdnf or Mtor gene expression, but in FSL rats the treatment with ketamine increased only Bdnf gene expression. Ketamine brain-derived neurotrophic factor Rattus norvegicus