Pub. Date : 2017
PMID : 28934275
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The activation of AKT by sorafenib is thought to be responsible for the development of these characteristics. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Two sorafenib-resistant HCC cell lines, established from human HCC HepG2 and Huh7 cells, were refractory to sorafenib-induced growth inhibition but were sensitive to MK-2206, a novel allosteric AKT inhibitor. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Thus, the combination of sorafenib and MK-2206 led to significant reversion of the EMT phenotype and P-gp-mediated MDR by downregulating phosphorylated AKT. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | These findings underscore the significance of EMT, MDR and enhanced PI3K/AKT signaling in sorafenib-resistant HCC cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |