Title : Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells.

Pub. Date : 2017

PMID : 28934275






1 Functional Relationships(s)
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1 Thus, the combination of sorafenib and MK-2206 led to significant reversion of the EMT phenotype and P-gp-mediated MDR by downregulating phosphorylated AKT. MK 2206 ATP binding cassette subfamily B member 1 Homo sapiens