Title : KATP channel block inhibits the Toll-like receptor 2-mediated stimulation of NF-κB by suppressing the activation of Akt, mTOR, JNK and p38-MAPK.

Pub. Date : 2017 Nov 15

PMID : 28923349






1 Functional Relationships(s)
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1 Inhibitors of c-JNK (SP600125) and p38-MAPK (SB203580) attenuated the lipoteichoic acid- or peptidoglycan-induced production of inflammatory mediators, the activation of the JNK and p38-MAPK, and the production of reactive oxygen species in keratinocytes. SB 203580 mitogen-activated protein kinase 8 Homo sapiens