Title : Pro-inflammatory chitosan/poly(γ-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity.

Pub. Date : 2017 Nov

PMID : 28919508






2 Functional Relationships(s)
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1 Interestingly, Ch/gamma-PGA NPs, prepared by co-acervation method, induced an immunostimulatory DCs phenotype, enhancing the expression of the co-stimulatory molecules CD86, CD40 and HLA-DR, and the secretion of the pro-inflammatory cytokines TNF-alpha, IL-12p40 and IL-6. poly(gamma-glutamic acid) tumor necrosis factor Homo sapiens
2 Furthermore, Ch/gamma-PGA NPs re-educated IL-10-stimulated macrophages towards a pro-inflammatory profile, decreasing the expression of CD163 and promoting the secretion of IL-12p40 and TNF-alpha. poly(gamma-glutamic acid) tumor necrosis factor Homo sapiens