Title : Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus.

Pub. Date : 2017 Dec 15

PMID : 28919467






3 Functional Relationships(s)
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1 PURPOSE: Spleen tyrosine kinase (Syk) has been shown to phosphorylate tyrosine 18 of tau in vitro. Tyrosine microtubule associated protein tau Homo sapiens
2 To investigate this possibility we have studied Syk and tau phosphorylated at tyrosine 18 (pTyr18) in transgenic mice and human hippocampi. Tyrosine microtubule associated protein tau Homo sapiens
3 It possibly phosphorylates tyrosine 18 of tau and regulates other tau kinases in neurons with a fibrillary tau pathology. Tyrosine microtubule associated protein tau Homo sapiens