Pub. Date : 2017 Oct 17
PMID : 28902505
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosinase (EC 1.14.18.1), which possesses two copper ions at the active center, catalyzes a rate-limiting reaction of melanogenesis, that is, the conversion of a phenol to the corresponding ortho-quinone. | Copper | tyrosinase | Homo sapiens |
| 2 | Under physiological conditions, the addition of the copper ion to the complex releases tyrosinase from the complex, in accordance with the aggregation of the caddie protein. | Copper | tyrosinase | Homo sapiens |
| 3 | The release of the copper-bound tyrosinase was found to be accelerated by adding reducing agents under aerobic conditions. | Copper | tyrosinase | Homo sapiens |
| 4 | Electron paramagnetic resonance analysis under anaerobic conditions and Fourier transform infrared spectroscopic analysis using CO as a structural probe under anaerobic conditions indicated that the copper transportation process to the active center is a reversible event in the tyrosinase/caddie complex. | Copper | tyrosinase | Homo sapiens |