Pub. Date : 2017 Nov
PMID : 28901458
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF in a rat model. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |
| 5 | In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF. | Curcumin | nitric oxide synthase 2 | Rattus norvegicus |