Pub. Date : 2017 Nov 15
PMID : 28899696
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization. | Disulfides | 5-hydroxytryptamine receptor 2A | Homo sapiens |
| 2 | The serotonin 2A (5-HT2A) receptor is a G-protein coupled receptor (GPCR) with a conserved disulfide bridge formed by Cys148 (transmembrane helix 3, TM3) and Cys227 (extracellular loop 2, ECL-2). | Disulfides | 5-hydroxytryptamine receptor 2A | Homo sapiens |
| 3 | We hypothesized that disulfide bridges may determine serotonin 5-HT2A receptor functions such as receptor activation, functional selectivity and ligand recognition. | Disulfides | 5-hydroxytryptamine receptor 2A | Homo sapiens |