Pub. Date : 2017 Dec
PMID : 28893618
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lenalidomide modulates gene expression in human ABC-DLBCL cells by regulating IKAROS interaction with an intronic control region of SPIB. | Lenalidomide | IKAROS family zinc finger 1 | Homo sapiens |
| 2 | Lenalidomide, an immunomodulatory drug in trials for treatment of ABC-DLBCL, targets the transcription factor IKAROS for degradation by the cereblon E3 ubiquitin ligase complex. | Lenalidomide | IKAROS family zinc finger 1 | Homo sapiens |
| 3 | These results show that the mechanism of action of lenalidomide in ABC-DLBCL cells involves downregulation of SPIB transcription by cereblon-induced degradation of IKAROS. | Lenalidomide | IKAROS family zinc finger 1 | Homo sapiens |