Title : CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone.

Pub. Date : 2017 Nov

PMID : 28890368






1 Functional Relationships(s)
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1 Co-administration of Abi lead to detectable concentrations of the Abi metabolite Delta4-Abi (D4A), known to inhibit enzymes other than CYP17A1 in steroid metabolism. delta4-abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens