Pub. Date : 2017 Nov
PMID : 28888780
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-kappaB signaling pathway in RAW264.7 cells. | Berberine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | Further mechanistic studies revealed that BBR-induced inhibition of NF-kappaB is Sirt1-dependent, as either pharmacologically or genetically inactivating Sirt1 enhanced the IkappaBetaalpha degradation, IKK phosphorylation, NF-kappaB p65 acetylation and DNA-binding activity. | Berberine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | Further mechanistic studies revealed that BBR-induced inhibition of NF-kappaB is Sirt1-dependent, as either pharmacologically or genetically inactivating Sirt1 enhanced the IkappaBetaalpha degradation, IKK phosphorylation, NF-kappaB p65 acetylation and DNA-binding activity. | Berberine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |