Title : Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells.

Pub. Date : 2017 Aug 1

PMID : 28881582






2 Functional Relationships(s)
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Protein Name
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1 Metformin inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which is frequently upregulated in hepatocellular carcinoma (HCC). Metformin CREB regulated transcription coactivator 1 Mus musculus
2 Here, we investigate whether metformin-induced apoptosis in HCC is mediated by the downstream mTORC1 effectors eukaryotic initiation factor 4E and (eIF4E)-binding proteins (4E-BPs). Metformin CREB regulated transcription coactivator 1 Mus musculus