Title : Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.

Pub. Date : 2017 Oct 2

PMID : 28872461






2 Functional Relationships(s)
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1 Mechanistic studies revealed that trihydroxyphenolics induce auto-oxidation of a LOXL2/3-specific lysine (K731) in a time-dependent reaction that irreversibly inhibits LOXL2 and converts the trihydrophenolic to a previously undescribed metabolite that directly inhibits TbetaRI kinase. Lysine lysyl oxidase like 2 Homo sapiens
2 Mechanistic studies revealed that trihydroxyphenolics induce auto-oxidation of a LOXL2/3-specific lysine (K731) in a time-dependent reaction that irreversibly inhibits LOXL2 and converts the trihydrophenolic to a previously undescribed metabolite that directly inhibits TbetaRI kinase. Lysine lysyl oxidase like 2 Homo sapiens