| Protein Name | lysyl oxidase like 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4017 |
| Gene Symbol | LOXL2 |
| UniProt | Q9Y4K0 (LOXL2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
76
Total Number of Articles : 81 |
Description |
lysyl oxidase like 2 |
| Gene Summary |
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] |
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