Pub. Date : 2018 Feb
PMID : 28857504
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | A history of nicotine exposure significantly decreased H3K14 acetylation at the brain-derived neurotrophic factor (BDNF) exon IV promoter, and this effect was abolished with NaB treatment. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | A history of nicotine exposure significantly decreased H3K14 acetylation at the brain-derived neurotrophic factor (BDNF) exon IV promoter, and this effect was abolished with NaB treatment. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | In contrast, nicotine self-administration alone, resulted in a significant decrease in histone methylation at the H3K27me3 and H3K9me2 marks in the promoter regions of BDNF exon IV and cyclin-dependent kinase 5 (Cdk-5). | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | Quantitative PCR-identified changes in several genes associated with NaB treatment that were independent of nicotine exposure; however, an interaction of nicotine history and NaB treatment was detected only in the expression of BDNF IV and BDNF IX. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 6 | Quantitative PCR-identified changes in several genes associated with NaB treatment that were independent of nicotine exposure; however, an interaction of nicotine history and NaB treatment was detected only in the expression of BDNF IV and BDNF IX. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 7 | Together these results suggest that nicotine self-administration leads to a number of epigenetic changes at both the BDNF and Cdk-5 promoters, and that these changes may contribute to the enhanced extinction of nicotine-seeking by NaB. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 8 | Together these results suggest that nicotine self-administration leads to a number of epigenetic changes at both the BDNF and Cdk-5 promoters, and that these changes may contribute to the enhanced extinction of nicotine-seeking by NaB. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |