Title : Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging.

Pub. Date : 2017 Oct 15

PMID : 28842332






2 Functional Relationships(s)
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1 STATEMENT OF SIGNIFICANCE: In this study, we report the synthesis of the tumor acidity-activatable amorphous porous manganese phosphate nanoparticles and their application for a photoactivable synergistic nanosystem that imparts reactive oxygen species (ROS) induced cytotoxicity in synchrony with hypoxia-inducible factor 1alpha/vascular endothelial growth factor (HIF-1alpha/VEGF) inhibitor that suppresses tumor growth and treatment escape signalling pathway. Reactive Oxygen Species vascular endothelial growth factor A Homo sapiens
2 STATEMENT OF SIGNIFICANCE: In this study, we report the synthesis of the tumor acidity-activatable amorphous porous manganese phosphate nanoparticles and their application for a photoactivable synergistic nanosystem that imparts reactive oxygen species (ROS) induced cytotoxicity in synchrony with hypoxia-inducible factor 1alpha/vascular endothelial growth factor (HIF-1alpha/VEGF) inhibitor that suppresses tumor growth and treatment escape signalling pathway. Reactive Oxygen Species vascular endothelial growth factor A Homo sapiens