Pub. Date : 2017 Oct 21
PMID : 28842253
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Repression of ESR1 transcription by MYOD potentiates letrozole-resistance in ERalpha-positive breast cancer cells. | Letrozole | estrogen receptor 1 | Homo sapiens |
| 2 | Repression of ESR1 transcription by MYOD potentiates letrozole-resistance in ERalpha-positive breast cancer cells. | Letrozole | estrogen receptor 1 | Homo sapiens |
| 3 | Transcriptional silencing of estrogen receptor alpha (ERalpha) expression is an important etiology contributing to the letrozole-resistance in ERalpha-positive breast cancer (BCa) cells, but the transcription factors responsible for this transcriptional repression remain largely unidentified. | Letrozole | estrogen receptor 1 | Homo sapiens |
| 4 | Transcriptional silencing of estrogen receptor alpha (ERalpha) expression is an important etiology contributing to the letrozole-resistance in ERalpha-positive breast cancer (BCa) cells, but the transcription factors responsible for this transcriptional repression remain largely unidentified. | Letrozole | estrogen receptor 1 | Homo sapiens |
| 5 | Transcriptional silencing of estrogen receptor alpha (ERalpha) expression is an important etiology contributing to the letrozole-resistance in ERalpha-positive breast cancer (BCa) cells, but the transcription factors responsible for this transcriptional repression remain largely unidentified. | Letrozole | estrogen receptor 1 | Homo sapiens |
| 6 | Mechanistically, MYOD was shown to be a potent corepressor of ESR1 transcription, and this transcriptional repression was significantly enhanced in the presence of letrozole treatment. | Letrozole | estrogen receptor 1 | Homo sapiens |