Pub. Date : 2017 Oct
PMID : 28822725
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine, which is the main active component of the traditional medicinal herb Coptidis rhizoma, has a positive effect on reducing Abeta levels. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | The results indicate that berberine reduces Abeta generation and decreases the expression of beta-site APP cleaving enzyme-1 (BACE1) via activating AMPK in N2a mouse neuroblastoma cells stably expressing human Swedish mutant APP695 (N2a/APP695sw), N2a cells, and primary cultured cortical neurons. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | Therefore, berberine reduced the accumulation of Abeta, which likely contributes to its memory enhancing effect in patients with AD. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |