Title : Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin.

Pub. Date : 2017 Oct 6

PMID : 28821617






2 Functional Relationships(s)
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1 In this report, we characterize the structural determinants responsible for Jak3 interactions with beta-catenin and determine the functional implications of previously unknown tyrosine residues on beta-catenin phosphorylated by Jak3. Tyrosine catenin beta 1 Homo sapiens
2 We demonstrate that Jak3 autophosphorylation was the rate-limiting step during Jak3 trans-phosphorylation of beta-catenin, where Jak3 directly phosphorylated three tyrosine residues, viz. Tyrosine catenin beta 1 Homo sapiens