Pub. Date : 1987 May
PMID : 2881980
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Incubation of rat pheochromocytoma PC12 cells with 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), an activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), or forskolin, an activator of adenylate cyclase, is associated with increased activity and enhanced phosphorylation of tyrosine hydroxylase. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 2 | However, in cells treated with either PMA or forskolin, there is an increase in the phosphorylation of only one of these peptides derived from tyrosine hydroxylase. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 3 | These results indicate that tyrosine hydroxylase is activated and phosphorylated on different sites in PC12 cells exposed to PMA and forskolin and that phosphorylation of either of these sites is associated with activation of tyrosine hydroxylase. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 4 | These results indicate that tyrosine hydroxylase is activated and phosphorylated on different sites in PC12 cells exposed to PMA and forskolin and that phosphorylation of either of these sites is associated with activation of tyrosine hydroxylase. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |