Title : NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.

Pub. Date : 2017 Oct

PMID : 28806703






3 Functional Relationships(s)
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1 NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin. Curcumin MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Among apoptosis-related proteins, thioridazine plus curcumin induced down-regulation of c-FLIP and Mcl-1 expression at the post-translational levels in a proteasome-dependent manner. Curcumin MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 Furthermore, ectopic expression of c-FLIP and Mcl-1 inhibited apoptosis in thioridazine and curcumin-treated cells. Curcumin MCL1 apoptosis regulator, BCL2 family member Homo sapiens